Protein Function Prediction by Matching Volumetric Models of Active Sites
نویسندگان
چکیده
The goal of the proposed project is to develop an algorithm for predicting the molecular function of a protein from a structural model of its active sites. Given the 3D atomic coordinates for a novel protein and the location of a ligand binding site, we build a model of the site cavity, match it against a database of active sites models having known molecular functions, and make predictions based on the functional annotations associated with the best matches.
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تاریخ انتشار 2006